PrimePCR™ ddPCR™ Expression Probe Assay: Htr2c, Mouse


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qMmuCEP0056908; exonic

Fluorophore:   FAM
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dMmuCPE5100674
Chromosome Location:   X:147075917-147169585question
Amplicon Length:   117

Gene Information

Serotonin (5-hydroxytryptamine 5-HT) a neurotransmitter elicits a wide array of physiological effects by binding to several receptor subtypes including the 5-HT2 family of seven-transmembrane-spanning G-protein-coupled receptors which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades thus modulating serotonergic neurotransmission in the central nervous system. Studies in rodents show altered patterns of RNA editing in response to drug treatments and stressful situations. [provided by RefSeq Jul 2008]

Gene Symbol:   Htr2c
Gene Name:   5-hydroxytryptamine (serotonin) receptor 2C
Aliases:   5-HT2C, 5-HT2cR, 5-HTR2C, 5HT1c, Htr1c, SR1
RefSeq:   NC_000086.7 NT_039718.8
Ensembl:   ENSMUSG00000041380
Entrez:   15560
UniGene:   Mm.439670
Chromosome Mapping:   X D-F4|X 66.15 cM

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