PrimePCR™ ddPCR™ Mutation Assay:ALK p.F1174L, Human


ddPCR probe assay designed for mutation detection. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   65nt amplicon; crosses exon-intron junction; in silico

Fluorophore:   FAM
List Price:    $335.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Mutation Detection in silico design
Unique Assay ID:   dHsaIS2505978
Chromosome Location:   2:29443636-29443758question
Amplicon Length:   65
Reference Assays:  
Restriction Enzymes:   HaeIII

Gene Information

This gene encodes a receptor tyrosine kinase which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain an hydrophobic stretch corresponding to a single pass transmembrane region and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged mutated or amplified in a series of tumours including anaplastic large cell lymphomas neuroblastoma and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene which result in creation of multiple fusion genes in tumourigenesis including ALK (chromosome 2)/EML4 (chromosome 2) ALK/RANBP2 (chromosome 2) ALK/ATIC (chromosome 2) ALK/TFG (chromosome 3) ALK/NPM1 (chromosome 5) ALK/SQSTM1 (chromosome 5) ALK/KIF5B (chromosome 10) ALK/CLTC (chromosome 17) ALK/TPM4 (chromosome 19) and ALK/MSN (chromosome X).[provided by RefSeq Jan 2011]

Gene Symbol:   ALK
Gene Name:   anaplastic lymphoma receptor tyrosine kinase
Aliases:   CD246, NBLST3
RefSeq:   NC_000002.11 NG_009445.1 NT_022184.15
Ensembl:   ENSG00000171094
Entrez:   238
UniGene:   Hs.654469
Chromosome Mapping:   2p23

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