PrimePCR™ ddPCR™ Mutation Assay:SF3B1 WT for p.R625C, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR probe assay designed for mutation detection. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   77nt amplicon; exonic; in silico

 
Fluorophore:   HEX
List Price:    $325.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Mutation Detection in silico design
Unique Assay ID:   dHsaIS2505505
Chromosome Location:   2:198267423-198267545question
Amplicon Length:   77
Restriction Enzymes:   HaeIII

Gene Information

This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b together with splicing factor 3a and a 12S RNA unit forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical tandem HEAT repeats that form rod-like helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq Jul 2008]

Gene Symbol:   SF3B1
Gene Name:   splicing factor 3b, subunit 1, 155kDa
Aliases:   Hsh155, PRP10, PRPF10, SAP155, SF3b155
RefSeq:   NC_000002.11 NT_005403.17
Ensembl:   ENSG00000115524
Entrez:   23451
UniGene:   Hs.632554
Chromosome Mapping:   2q33.1

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