PrimePCR™ ddPCR™ Mutation Assay:APC WT for p.Q1429*, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR probe assay designed for mutation detection. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   70nt amplicon; exonic; in silico

 
Fluorophore:   HEX
List Price:    $325.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Mutation Detection in silico design
Unique Assay ID:   dHsaIS2505379
Chromosome Location:   5:112175515-112175637question
Amplicon Length:   70
Restriction Enzymes:   HaeIII

Gene Information

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion transcriptional activation and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP) an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq Jul 2008]

Gene Symbol:   APC
Gene Name:   adenomatous polyposis coli
Aliases:   BTPS2, DP2, DP2.5, DP3, GS
RefSeq:   NC_000005.9 NG_008481.4 NT_034772.6
Ensembl:   ENSG00000134982
Entrez:   324
UniGene:   Hs.158932
Chromosome Mapping:   5q21-q22

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