PrimePCR™ ddPCR™ Mutation Assay:MET p.T1010I, Human


ddPCR probe assay designed for mutation detection. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   70nt amplicon; exonic; in silico

Fluorophore:   FAM
List Price:    $335.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Mutation Detection in silico design
Unique Assay ID:   dHsaIS2503878
Chromosome Location:   7:116411929-116412051question
Amplicon Length:   70
Reference Assays:  
Restriction Enzymes:   HaeIII

Gene Information

The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Jul 2008]

Gene Symbol:   MET
Gene Name:   met proto-oncogene (hepatocyte growth factor receptor)
Aliases:   AUTS9, HGFR, RCCP2, c-Met
RefSeq:   NC_000007.13 NT_007933.15 NG_008996.1
Ensembl:   ENSG00000105976
Entrez:   4233
UniGene:   Hs.132966
Chromosome Mapping:   7q31

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