PrimePCR™ ddPCR™ Mutation Assay:KRAS p.G13S, Human

PrimePCR

ddPCR probe assay designed for mutation detection. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   90nt amplicon; crosses exon-intron junction; in silico

 
Fluorophore:   FAM
List Price:    $335.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Mutation Detection in silico design
Unique Assay ID:   dHsaIS2503596
Chromosome Location:   12:25398221-25398343question
Amplicon Length:   90
Reference Assays:  
Restriction Enzymes:   MseI

Gene Information

This gene a Kirsten ras oncogene homolog from the mammalian ras gene family encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies including lung adenocarcinoma mucinous adenoma ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq Jul 2008]

Gene Symbol:   KRAS
Gene Name:   v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Aliases:   C-K-RAS, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, KRAS1, KRAS2, NS, NS3, RASK2
RefSeq:   NC_000012.11 NG_007524.1 NT_009714.17
Ensembl:   ENSG00000133703
Entrez:   3845
UniGene:   Hs.505033
Chromosome Mapping:   12p12.1

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