PrimePCR™ ddPCR™ Mutation Assay:HRAS WT for p.G13C, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR probe assay designed for mutation detection. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   63nt amplicon; exonic; in silico

 
Fluorophore:   HEX
List Price:    $325.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Mutation Detection in silico design
Unique Assay ID:   dHsaIS2502745
Chromosome Location:   11:534225-534347question
Amplicon Length:   63
Restriction Enzymes:   HaeIII

Gene Information

This gene belongs to the Ras oncogene family whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome a disease characterized by increased growth at the prenatal stage growth deficiency at the postnatal stage predisposition to tumor formation mental retardation skin and musculoskeletal abnormalities distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers including bladder cancer follicular thyroid cancer and oral squamous cell carcinoma. Multiple transcript variants which encode different isoforms have been identified for this gene. [provided by RefSeq Jul 2008]

Gene Symbol:   HRAS
Gene Name:   v-Ha-ras Harvey rat sarcoma viral oncogene homolog
Aliases:   C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, K-RAS, N-RAS, RASH1
RefSeq:   NC_000011.9 NT_009237.18 NG_007666.1
Ensembl:   ENSG00000174775
Entrez:   3265
UniGene:   Hs.37003
Chromosome Mapping:   11p15.5

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