PrimePCR™ ddPCR™ Mutation Assay:PTEN WT for p.R233*, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR probe assay designed for mutation detection. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   114nt amplicon; crosses exon-intron junction; in silico

 
Fluorophore:   HEX
List Price:    $325.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Mutation Detection in silico design
Unique Assay ID:   dHsaIS2502615
Chromosome Location:   10:89717611-89717733question
Amplicon Length:   114
Restriction Enzymes:   HaeIII

Gene Information

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-345-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-345-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq Jul 2008]

Gene Symbol:   PTEN
Gene Name:   phosphatase and tensin homolog
Aliases:   10q23del, BZS, DEC, GLM2, MGC11227, MHAM, MMAC1, PTEN1, TEP1
RefSeq:   NC_000010.10 NG_007466.1 NT_030059.13
Ensembl:   ENSG00000171862
Entrez:   5728
UniGene:   Hs.500466
Chromosome Mapping:   10q23.3

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