PrimePCR™ ddPCR™ Mutation Assay:IKZF3 WT for p.L162R, Human

PrimePCR

ddPCR probe assay designed for mutation detection. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   84nt amplicon; exonic; in silico

 
Fluorophore:   HEX
List Price:    $335.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Mutation Detection in silico design
Unique Assay ID:   dHsaIS2502483
Chromosome Location:   17:37947715-37947837question
Amplicon Length:   84
Restriction Enzymes:   HaeIII

Gene Information

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers Ikaros/Aiolos heterodimers and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described as well as some non-protein coding variants. [provided by RefSeq Apr 2012]

Gene Symbol:   IKZF3
Gene Name:   IKAROS family zinc finger 3 (Aiolos)
Aliases:   AIO, AIOLOS, ZNFN1A3
RefSeq:   NC_000017.10 NT_010783.15
Ensembl:   ENSG00000161405
Entrez:   22806
UniGene:   Hs.444388
Chromosome Mapping:   17q21

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