This is the amplicon context sequence in accordance with the minimum information for the publication of real-time quantitative PCR experiements (MIQE) guidelines. For more details, please refer to the following publication, "Primer Sequence Disclosure: A Clarification of the MIQE Guidelines."
ddPCR™ probe assay designed for mutation detection. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.
Info: 84nt amplicon; exonic; in silico
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers Ikaros/Aiolos heterodimers and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described as well as some non-protein coding variants. [provided by RefSeq Apr 2012]