PrimePCR™ ddPCR™ Mutation Assay:BRAF WT for p.D594G, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR probe assay designed for mutation detection. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   91nt amplicon; exonic; in silico

 
Fluorophore:   HEX
List Price:    $325.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Mutation Detection in silico design
Unique Assay ID:   dHsaIS2502369
Chromosome Location:   7:140453093-140453215question
Amplicon Length:   91
Restriction Enzymes:   HaeIII

Gene Information

This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway which affects cell division differentiation and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome a disease characterized by heart defects mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers including non-Hodgkin lymphoma colorectal cancer malignant melanoma thyroid carcinoma non-small cell lung carcinoma and adenocarcinoma of lung. A pseudogene which is located on chromosome X has been identified for this gene. [provided by RefSeq Jul 2008]

Gene Symbol:   BRAF
Gene Name:   v-raf murine sarcoma viral oncogene homolog B1
Aliases:   B-RAF1, BRAF1, FLJ95109, MGC126806, MGC138284, NS7, RAFB1
RefSeq:   NC_000007.13 NG_007873.1 NT_007914.15
Ensembl:   ENSG00000157764
Entrez:   673
UniGene:   Hs.550061
Chromosome Mapping:   7q34

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