PrimePCR™ ddPCR™ Mutation Assay:NOTCH1 WT for p.L1600P, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR probe assay designed for mutation detection. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   65nt amplicon; exonic; in silico

 
Fluorophore:   HEX
List Price:    $325.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Mutation Detection in silico design
Unique Assay ID:   dHsaIS2502005
Chromosome Location:   9:139399283-139399405question
Amplicon Length:   65
Restriction Enzymes:   HaeIII

Gene Information

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats and an intracellular domain consisting of multiple different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia notch interaction with its cell-bound ligands (delta serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands and may play multiple roles during development. [provided by RefSeq Jul 2008]

Gene Symbol:   NOTCH1
Gene Name:   notch 1
Aliases:   TAN1, hN1
RefSeq:   NC_000009.11 NG_007458.1 NT_024000.16
Ensembl:   ENSG00000148400
Entrez:   4851
UniGene:   Hs.495473
Chromosome Mapping:   9q34.3

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