PrimePCR™ ddPCR™ Mutation Assay:DNMT3A p.R749C, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR probe assay designed for mutation detection. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   63nt amplicon; exonic; in silico

 
Fluorophore:   FAM
List Price:    $325.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Mutation Detection in silico design
Unique Assay ID:   dHsaIS2501996
Chromosome Location:   2:25463187-25463309question
Amplicon Length:   63
Reference Assays:   DNMT3A(dHsaIS2501997)
Restriction Enzymes:   MseI

Gene Information

CpG methylation is an epigenetic modification that is important for embryonic development imprinting and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq Jul 2008]

Gene Symbol:   DNMT3A
Gene Name:   DNA (cytosine-5-)-methyltransferase 3 alpha
Aliases:   DNMT3A2, M.HsaIIIA
RefSeq:   NC_000002.11 NT_022184.15
Ensembl:   ENSG00000119772
Entrez:   1788
UniGene:   Hs.515840
Chromosome Mapping:   2p23

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