PrimePCR™ ddPCR™ Mutation Assay:PDGFRA WT for p.N659K, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR probe assay designed for mutation detection. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   58nt amplicon; crosses exon-intron junction; in silico

Fluorophore:   HEX
List Price:    $325.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Mutation Detection in silico design
Unique Assay ID:   dHsaIS2501761
Chromosome Location:   4:55144087-55144209question
Amplicon Length:   58
Restriction Enzymes:   MseI

Gene Information

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development wound healing and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome somatic and familial gastrointestinal stromal tumors and a variety of other cancers. [provided by RefSeq Mar 2012]

Gene Symbol:   PDGFRA
Gene Name:   platelet-derived growth factor receptor, alpha polypeptide
Aliases:   CD140A, MGC74795, PDGFR2, RHEPDGFRA
RefSeq:   NC_000004.11 NG_009250.1 NT_022853.15
Ensembl:   ENSG00000134853
Entrez:   5156
UniGene:   Hs.74615
Chromosome Mapping:   4q12

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