PrimePCR™ ddPCR™ Mutation Assay:ABL1 WT for p.L248V, Human

PrimePCR

ddPCR probe assay designed for mutation detection. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   62nt amplicon; exonic; in silico

 
Fluorophore:   HEX
List Price:    $335.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Mutation Detection in silico design
Unique Assay ID:   dHsaIS2501311
Chromosome Location:   9:133738281-133738403question
Amplicon Length:   62
Restriction Enzymes:   MseI

Gene Information

The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation cell division cell adhesion and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq Jul 2008]

Gene Symbol:   ABL1
Gene Name:   c-abl oncogene 1, non-receptor tyrosine kinase
Aliases:   ABL, JTK7, bcr/abl, c-ABL, p150, v-abl
RefSeq:   NC_000009.11 NT_035014.4 NG_012034.1
Ensembl:   ENSG00000097007
Entrez:   25
UniGene:   Hs.431048
Chromosome Mapping:   9q34.1

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