This is the amplicon context sequence in accordance with the minimum information for the publication of real-time quantitative PCR experiements (MIQE) guidelines. For more details, please refer to the following publication, "Primer Sequence Disclosure: A Clarification of the MIQE Guidelines."
ddPCR™ Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.
Info: EG; Same primer pair as used in qPCR assay qHsaCID0021765; Intron-spanning
The protein encoded by this gene is a member of the CARD protein family which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). CARD is a protein interaction domain known to participate in activation or suppression of CARD containing members of the caspase family and thus plays an important regulatory role in cell apoptosis. This protein was identified by its selective association with the CARD domain of BCL10 a postive regulator of apoptosis and NF-kappaB activation and is thought to function as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-kappaB. Several alternatively spliced transcript variants have been observed but their full-length nature is not clearly defined. [provided by RefSeq Jul 2008]