PrimePCR™ ddPCR™ Expression EvaGreen® Assay: BRCC3, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCED0047753; exonic

List Price:    $134.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5189262
Chromosome Location:   X:154305445-154305549question
Amplicon Length:   75

Gene Information

This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC) which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq Jun 2011]

Gene Symbol:   BRCC3
Gene Name:   BRCA1/BRCA2-containing complex, subunit 3
Aliases:   BRCC36, C6.1A, CXorf53
RefSeq:   NC_000023.10 NG_005114.1 NT_167198.1
Ensembl:   ENSG00000185515
Entrez:   79184
UniGene:   Hs.558537
Chromosome Mapping:   Xq28

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