PrimePCR™ ddPCR™ Expression EvaGreen® Assay: PABPN1, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCED0037959; exonic

List Price:    $134.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5188685
Chromosome Location:   14:23793347-23793487question
Amplicon Length:   111

Gene Information

This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene. [provided by RefSeq Dec 2010]

Gene Symbol:   PABPN1
Gene Name:   poly(A) binding protein, nuclear 1
Aliases:   OPMD, PAB2, PABII, PABP-2, PABP2
RefSeq:   NC_000014.8 NG_008239.1 NT_026437.12
Ensembl:   ENSG00000100836
Entrez:   8106
UniGene:   Hs.707712
Chromosome Mapping:   14q11.2-q13

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