PrimePCR™ ddPCR™ Expression EvaGreen® Assay: HLA-DQB1, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCED0037172; exonic

List Price:    $134.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5188364
Chromosome Location:   6:32629896-32632587question
Amplicon Length:   112

Gene Information

HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB) both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes dendritic cells macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide exons 2 and 3 encode the two extracellular domains exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq Sep 2011]

Gene Symbol:   HLA-DQB1
Gene Name:   major histocompatibility complex, class II, DQ beta 1
Aliases:   CELIAC1, HLA-DQB, IDDM1
RefSeq:   NC_000006.11 NT_007592.15
Ensembl:   ENSG00000179344
Entrez:   3119
UniGene:   Hs.409934
Chromosome Mapping:   6p21.3

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