PrimePCR™ ddPCR™ Expression EvaGreen® Assay: NLRP3, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCID0036694; Intron-spanning

List Price:    $134.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5024977
Chromosome Location:   1:247582325-247586626question
Amplicon Length:   120

Gene Information

This gene encodes a pyrin-like protein containing a pyrin domain a nucleotide-binding site (NBS) domain and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC which contains a caspase recruitment domain and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling and it plays a role in the regulation of inflammation the immune response and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS) Muckle-Wells syndrome (MWS) chronic infantile neurological cutaneous and articular (CINCA) syndrome and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq Oct 2008]

Gene Symbol:   NLRP3
Gene Name:   NLR family, pyrin domain containing 3
Aliases:   AGTAVPRL, AII, AII/AVP, AVP, C1orf7, CIAS1, CLR1.1, FCAS, FCU, FLJ95925, MWS, NALP3, PYPAF1
RefSeq:   NC_000001.10 NT_167186.1 NG_007509.2
Ensembl:   ENSG00000162711
Entrez:   114548
UniGene:   Hs.159483
Chromosome Mapping:   1q44

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