PrimePCR™ ddPCR™ Expression EvaGreen® Assay: PCBP2, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCID0022772; Intron-spanning

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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5024566
Chromosome Location:   12:53862569-53865553question
Amplicon Length:   150

Gene Information

The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1 this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA human papillomavirus type 16 L2 mRNA and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1 an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Jul 2008]

Gene Symbol:   PCBP2
Gene Name:   poly(rC) binding protein 2
Aliases:   HNRPE2, MGC110998, hnRNP-E2
RefSeq:   NC_000012.11 NT_029419.12
Ensembl:   ENSG00000197111
Entrez:   5094
UniGene:   Hs.546271
Chromosome Mapping:   12q13.12-q13.13

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