This is the amplicon context sequence in accordance with the minimum information for the publication of real-time quantitative PCR experiements (MIQE) guidelines. For more details, please refer to the following publication, "Primer Sequence Disclosure: A Clarification of the MIQE Guidelines."
ddPCR™ Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.
Info: EG; Same primer pair as used in qPCR assay qHsaCID0018467; Intron-spanning
This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein like other neurexin proteins contains epidermal growth factor repeats and laminin G domains. In addition it includes an F5/8 type C domain discoidin/neuropilin- and fibrinogen-like domains thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2) a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders including Gilles de la Tourette syndrome schizophrenia epilepsy autism ADHD and mental retardation.[provided by RefSeq Mar 2010]