This is the amplicon context sequence in accordance with the minimum information for the publication of real-time quantitative PCR experiements (MIQE) guidelines. For more details, please refer to the following publication, "Primer Sequence Disclosure: A Clarification of the MIQE Guidelines."
ddPCR™ Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.
Info: EG; Same primer pair as used in qPCR assay qHsaCID0017658; Intron-spanning
The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells and this protein also functions as a chaperone in association with Bag3 a stimulator of macroautophagy. Thus this gene appears to be involved in regulation of cell proliferation apoptosis and carcinogenesis and mutations in this gene have been associated with different neuromuscular diseases including Charcot-Marie-Tooth disease. [provided by RefSeq Jul 2008]