PrimePCR™ ddPCR™ Expression EvaGreen® Assay: DOCK3, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCID0016308; Intron-spanning

List Price:    $134.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5021557
Chromosome Location:   3:51392413-51393594question
Amplicon Length:   87

Gene Information

This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein dedicator of cytokinesis 3 (DOCK3) is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1 -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq Aug 2010]

Gene Symbol:   DOCK3
Gene Name:   dedicator of cytokinesis 3
Aliases:   KIAA0299, MOCA, PBP
RefSeq:   NG_012652.2 NC_000003.11 NG_028012.1 NT_022517.18 NW_003315910.1
Ensembl:   ENSG00000088538
Entrez:   1795
UniGene:   Hs.476284
Chromosome Mapping:   3p21.2

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