PrimePCR™ ddPCR™ Expression EvaGreen® Assay: GUCA1A, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCID0016277; Intron-spanning

List Price:    $134.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5021531
Chromosome Location:   6:42141501-42146064question
Amplicon Length:   69

Gene Information

This gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein encoded by this gene guanylyl cyclase activating protein 1 (GCAP1) mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3); a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations; causing the constitutive activation of RetGC1 and presumably increased cell death. This gene is expressed in retina and spermatagonia. [provided by RefSeq Feb 2009]

Gene Symbol:   GUCA1A
Gene Name:   guanylate cyclase activator 1A (retina)
Aliases:   C6orf131, COD3, CORD14, GCAP, GCAP1, GUCA, GUCA1, dJ139D8.6
RefSeq:   NC_000006.11 NG_009938.1 NT_007592.15
Ensembl:   ENSG00000048545
Entrez:   2978
UniGene:   Hs.92858
Chromosome Mapping:   6p21.1

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