PrimePCR™ ddPCR™ Expression EvaGreen® Assay: MAP3K3, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCID0016260; Intron-spanning

List Price:    $134.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5021515
Chromosome Location:   17:61700066-61710152question
Amplicon Length:   140

Gene Information

This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases including mouse Mekk2 tobacco NPK and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq Jul 2008]

Gene Symbol:   MAP3K3
Gene Name:   mitogen-activated protein kinase kinase kinase 3
Aliases:   MAPKKK3, MEKK3
RefSeq:   NC_000017.10 NT_010783.15
Ensembl:   ENSG00000198909
Entrez:   4215
UniGene:   Hs.29282
Chromosome Mapping:   17q23.3

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