PrimePCR™ ddPCR™ Expression EvaGreen® Assay: PPM1D, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCID0016220; Intron-spanning

List Price:    $134.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5021479
Chromosome Location:   17:58725337-58733986question
Amplicon Length:   104

Gene Information

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53 this phosphatase negatively regulates the activity of p38 MAP kinase MAPK/p38 through which it reduces the phosphorylation of p53 and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors which suggests a role of this gene in cancer development. [provided by RefSeq Jul 2008]

Gene Symbol:   PPM1D
Gene Name:   protein phosphatase, Mg2+/Mn2+ dependent, 1D
Aliases:   PP2C-DELTA, WIP1
RefSeq:   NC_000017.10 NG_023265.1 NT_010783.15
Ensembl:   ENSG00000170836
Entrez:   8493
UniGene:   Hs.286073
Chromosome Mapping:   17q23.2

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