PrimePCR™ ddPCR™ Expression EvaGreen® Assay: BCR, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCID0013591; Intron-spanning

List Price:    $134.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5019441
Chromosome Location:   22:23613739-23615922question
Amplicon Length:   166

Gene Information

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Jul 2008]

Gene Symbol:   BCR
Gene Name:   breakpoint cluster region
Aliases:   ALL, BCR1, CML, D22S11, D22S662, FLJ16453, PHL
RefSeq:   NC_000022.10 NG_009244.1 NT_011520.12
Ensembl:   ENSG00000186716
Entrez:   613
UniGene:   Hs.517461
Chromosome Mapping:   22q11,22q11.23

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