PrimePCR™ ddPCR™ Expression EvaGreen® Assay: CR1, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCID0013379; Intron-spanning

List Price:    $134.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5019288
Chromosome Location:   1:207780619-207782678question
Amplicon Length:   77

Gene Information

This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes leukocytes glomerular podocytes and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas mesangiocapillary glomerulonephritis systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting conferring protection against severe malaria. Alternate allele-specific splice variants encoding different isoforms have been characterized. Additional allele specific isoforms including a secreted form have been described but have not been fully characterized. [provided by RefSeq Jul 2008]

Gene Symbol:   CR1
Gene Name:   complement component (3b/4b) receptor 1 (Knops blood group)
Aliases:   C3BR, C4BR, CD35, KN
RefSeq:   NC_000001.10 NG_007481.1 NT_167186.1
Ensembl:   ENSG00000203710
Entrez:   1378
UniGene:   Hs.334019
Chromosome Mapping:   1q32

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