PrimePCR™ ddPCR™ Expression EvaGreen® Assay: TRAF6, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCID0012893; Intron-spanning

List Price:    $130.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5018959
Chromosome Location:   11:36514162-36518742question
Amplicon Length:   144

Gene Information

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40 TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK SRC and PKCzeta which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13 and UBE2V1/UEV1A which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs a central coiled-coil region and a highly conserved carboxyl terminal domain known as the TRAF-C domain. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq Feb 2012]

Gene Symbol:   TRAF6
Gene Name:   TNF receptor-associated factor 6
Aliases:   MGC:3310, RNF85
RefSeq:   NC_000011.9 NT_009237.18
Ensembl:   ENSG00000175104
Entrez:   7189
UniGene:   Hs.444172
Chromosome Mapping:   11p12

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