PrimePCR™ ddPCR™ Expression EvaGreen® Assay: NUP98, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCID0012628; Intron-spanning

List Price:    $134.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5018774
Chromosome Location:   11:3742016-3744458question
Amplicon Length:   82

Gene Information

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC) which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5 an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome Wilms tumor rhabdomyosarcoma adrenocortical carcinoma and lung ovarian and breast cancer. Alternative splicing of this gene results in several transcript variants; however not all variants have been fully described. [provided by RefSeq May 2010]

Gene Symbol:   NUP98
Gene Name:   nucleoporin 98kDa
Aliases:   ADIR2, NUP196, NUP96
RefSeq:   NC_000011.9 NT_009237.18
Ensembl:   ENSG00000110713
Entrez:   4928
UniGene:   Hs.524750
Chromosome Mapping:   11p15.5

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