PrimePCR™ ddPCR™ Expression EvaGreen® Assay: DLAT, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCID0012546; Intron-spanning

List Price:    $134.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5018714
Chromosome Location:   11:111931847-111933180question
Amplicon Length:   73

Gene Information

This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene dihydrolipoamide acetyltransferase accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.[provided by RefSeq Oct 2009]

Gene Symbol:   DLAT
Gene Name:   dihydrolipoamide S-acetyltransferase
Aliases:   DLTA, PDC-E2, PDCE2
RefSeq:   NC_000011.9 NG_013342.1 NT_033899.8
Ensembl:   ENSG00000150768
Entrez:   1737
UniGene:   Hs.335551
Chromosome Mapping:   11q23.1

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