PrimePCR™ ddPCR™ Expression EvaGreen® Assay: ETV1, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCID0012502; Intron-spanning

List Price:    $134.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5018681
Chromosome Location:   7:13935603-13940430question
Amplicon Length:   148

Gene Information

This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth angiogenesis migration proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations which result in multiple fusion proteins including EWS-ETV1 in Erwing sarcoma and at least 10 ETV1 partners (see PMID: 19657377 Table 1) in prostate cancer. In addition to chromosomal rearrangement this gene is overexpressed in prostate cancer melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq Aug 2011]

Gene Symbol:   ETV1
Gene Name:   ets variant 1
Aliases:   DKFZp781L0674, ER81, MGC104699, MGC120533, MGC120534
RefSeq:   NC_000007.13 NT_007819.17
Ensembl:   ENSG00000006468
Entrez:   2115
UniGene:   Hs.22634
Chromosome Mapping:   7p21.3

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