PrimePCR™ ddPCR™ Expression EvaGreen® Assay: TAF4, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCID0012117; Intron-spanning

List Price:    $134.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5018410
Chromosome Location:   20:60574122-60575613question
Amplicon Length:   149

Gene Information

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID) which binds to the core promoter to position the polymerase properly serves as the scaffold for assembly of the remainder of the transcription complex and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription serve as coactivators function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid thyroid hormone and vitamin D3 receptors. In addition this subunit interacts with the transcription factor CREB which has a glutamine-rich activation domain and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases. [provided by RefSeq Jul 2008]

Gene Symbol:   TAF4
Gene Name:   TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
Aliases:   FLJ41943, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
RefSeq:   NC_000020.10 NT_011362.10
Ensembl:   ENSG00000130699
Entrez:   6874
UniGene:   Hs.18857
Chromosome Mapping:   20q13.33

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