PrimePCR™ ddPCR™ Expression EvaGreen® Assay: CHM, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCID0012100; Intron-spanning

List Price:    $138.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5018398
Chromosome Location:   X:85233852-85282542question
Amplicon Length:   135

Gene Information

This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid retinal pigment epithelium and retina. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq Feb 2009]

Gene Symbol:   CHM
Gene Name:   choroideremia (Rab escort protein 1)
Aliases:   DXS540, FLJ38564, GGTA, HSD-32, MGC102710, REP-1, TCD
RefSeq:   NC_000023.10 NG_009874.1 NT_011651.17
Ensembl:   ENSG00000188419
Entrez:   1121
UniGene:   Hs.496449
Chromosome Mapping:   Xq21.2

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