PrimePCR™ ddPCR™ Expression EvaGreen® Assay: MBD4, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCID0010609; Intron-spanning

List Price:    $134.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5017245
Chromosome Location:   3:129151985-129152734question
Amplicon Length:   118

Gene Information

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2 MBD1 MBD2 MBD3 and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins with the exception of MBD3 is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI) a form of genomic instability associated with defective DNA mismatch repair and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene. [provided by RefSeq Jul 2008]

Gene Symbol:   MBD4
Gene Name:   methyl-CpG binding domain protein 4
Aliases:   MED1
RefSeq:   NC_000003.11 NG_023392.1 NT_005612.16
Ensembl:   ENSG00000129071
Entrez:   8930
UniGene:   Hs.35947
Chromosome Mapping:   3q21.3

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