PrimePCR™ ddPCR™ Expression EvaGreen® Assay: FMO3, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCED0056971; exonic

List Price:    $138.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5013559
Chromosome Location:   1:171060118-171061920question
Amplicon Length:   102

Gene Information

Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-sulfur- and phosphorous-containing xenobiotics such as therapeutic drugs dietary compounds pesticides and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene the major FMO expressed in adult liver can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and therefore is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.[provided by RefSeq Aug 2009]

Gene Symbol:   FMO3
Gene Name:   flavin containing monooxygenase 3
Aliases:   FMOII, MGC34400, TMAU, dJ127D3.1
RefSeq:   NC_000001.10 NG_012690.1 NT_004487.19
Ensembl:   ENSG00000007933
Entrez:   2328
UniGene:   Hs.445350
Chromosome Mapping:   1q24.3

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