PrimePCR™ ddPCR™ Expression EvaGreen® Assay: HOGA1, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCED0048778; exonic

List Price:    $134.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5012962
Chromosome Location:   10:99372115-99372216question
Amplicon Length:   72

Gene Information

The authors of PMID:20797690 cloned this gene while searching for genes in a region of chromosome 10 linked to primary hyperoxalurea type III. They noted that even though the encoded protein has been described as a mitochondrial dihydrodipicolinate synthase-like enzyme it shares little homology with E. coli dihydrodipicolinate synthase (Dhdps) particularly in the putative substrate-binding region. Moreover neither lysine biosynthesis nor sialic acid metabolism for which Dhdps is responsible occurs in vertebrate mitochondria. They propose that this gene encodes mitochondrial 4-hydroxyl-2-oxoglutarate aldolase (EC which catalyzes the final step in the metabolic pathway of hydroxyproline releasing glyoxylate and pyruvate. This gene is predominantly expressed in the liver and kidney and mutations in this gene are found in patients with primary hyperoxalurea type III. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq Nov 2010]

Gene Symbol:   HOGA1
Gene Name:   4-hydroxy-2-oxoglutarate aldolase 1
Aliases:   C10orf65, DHDPS2, DHDPSL, FLJ37472, FLJ56960, HP3, NPL2
RefSeq:   NC_000010.10 NT_030059.13 NG_027922.1
Ensembl:   ENSG00000241935
Entrez:   112817
UniGene:   Hs.180346
Chromosome Mapping:   10q24.2

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