PrimePCR™ ddPCR™ Expression EvaGreen® Assay: COL4A3, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCED0046600; exonic

List Price:    $130.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5011030
Chromosome Location:   2:228177041-228177152question
Amplicon Length:   82

Gene Information

Type IV collagen the major structural component of basement membranes is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes alpha 1 through alpha 6 each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq Jun 2010]

Gene Symbol:   COL4A3
Gene Name:   collagen, type IV, alpha 3 (Goodpasture antigen)
Aliases:   Not Available
RefSeq:   NG_011592.1 NC_000002.11 NG_011591.1 NT_005403.17
Ensembl:   ENSG00000169031
Entrez:   1285
UniGene:   Hs.570065
Chromosome Mapping:   2q36-q37

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