This is the amplicon context sequence in accordance with the minimum information for the publication of real-time quantitative PCR experiements (MIQE) guidelines. For more details, please refer to the following publication, "Primer Sequence Disclosure: A Clarification of the MIQE Guidelines."
ddPCR™ Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.
Info: EG; Same primer pair as used in qPCR assay qHsaCED0046320; exonic
This gene encodes a protein containing a SET domain 2 LXXLL motifs 3 nuclear translocation signals (NLSs) 4 plant homeodomain (PHD) finger regions and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var enhancer of zeste and trithorax domain protein 1 on chromosome 5 and nucleoporin 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq Jul 2008]