PrimePCR™ ddPCR™ Expression EvaGreen® Assay: CHRNB3, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCED0045368; exonic

List Price:    $130.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5009917
Chromosome Location:   8:42552633-42563869question
Amplicon Length:   89

Gene Information

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are (hetero)pentamers composed of homologous subunits. The subunits that make up the muscle and neuronal forms of nAChRs are encoded by separate genes and have different primary structure. There are several subtypes of neuronal nAChRs that vary based on which homologous subunits are arranged around the central channel. They are classified as alpha-subunits if like muscle alpha-1 (MIM 100690) they have a pair of adjacent cysteines as part of the presumed acetylcholine binding site. Subunits lacking these cysteine residues are classified as beta-subunits (Groot Kormelink and Luyten 1997 [PubMed 9009220]). Elliott et al. (1996) [PubMed 8906617] stated that the proposed structure for each subunit is a conserved N-terminal extracellular domain followed by 3 conserved transmembrane domains a variable cytoplasmic loop a fourth conserved transmembrane domain and a short C-terminal extracellular region.[supplied by OMIM Apr 2010]

Gene Symbol:   CHRNB3
Gene Name:   cholinergic receptor, nicotinic, beta 3
Aliases:   Not Available
RefSeq:   NC_000008.10 NT_167187.1
Ensembl:   ENSG00000147432
Entrez:   1142
UniGene:   Hs.654576
Chromosome Mapping:   8p11.2

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