PrimePCR™ ddPCR™ Expression EvaGreen® Assay: HMGCR, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCED0043471; exonic

List Price:    $134.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5008239
Chromosome Location:   5:74656125-74656272question
Amplicon Length:   118

Gene Information

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Aug 2008]

Gene Symbol:   HMGCR
Gene Name:   3-hydroxy-3-methylglutaryl-CoA reductase
Aliases:   LDLCQ3
RefSeq:   NC_000005.9 NG_011449.1 NT_006713.15
Ensembl:   ENSG00000113161
Entrez:   3156
UniGene:   Hs.628096
Chromosome Mapping:   5q13.3-q14

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