PrimePCR™ ddPCR™ Expression EvaGreen® Assay: CBFA2T2, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCED0042423; exonic

List Price:    $138.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5007353
Chromosome Location:   20:32198978-32199111question
Amplicon Length:   104

Gene Information

In acute myeloid leukemia especially in the M2 subtype the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene but the full-length natures of only three have been described. [provided by RefSeq Jul 2008]

Gene Symbol:   CBFA2T2
Gene Name:   core-binding factor, runt domain, alpha subunit 2; translocated to, 2
Aliases:   DKFZp313F2116, EHT, MTGR1, ZMYND3, p85
RefSeq:   NC_000020.10 NT_011362.10
Ensembl:   ENSG00000078699
Entrez:   9139
UniGene:   Hs.153934
Chromosome Mapping:   20q11

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