PrimePCR™ ddPCR™ Expression EvaGreen® Assay: MRVI1, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCED0042329; exonic

List Price:    $130.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5007270
Chromosome Location:   11:10598030-10602021question
Amplicon Length:   83

Gene Information

This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein which is found in the membrane of the endoplasmic reticulum is similar to Jaw1 a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene and alternative translation start sites including a non-AUG (CUG) start site are used. [provided by RefSeq May 2011]

Gene Symbol:   MRVI1
Gene Name:   murine retrovirus integration site 1 homolog
Aliases:   IRAG, JAW1L
RefSeq:   NC_000011.9 NT_009237.18
Ensembl:   ENSG00000072952
Entrez:   10335
UniGene:   Hs.501898
Chromosome Mapping:   11p15

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