PrimePCR™ ddPCR™ Expression EvaGreen® Assay: NUB1, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCED0041989; exonic

List Price:    $134.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5006960
Chromosome Location:   7:151046201-151046312question
Amplicon Length:   82

Gene Information

This gene encodes a protein that functions as a negative regulator of NEDD8 a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene which is associated with Leber congenital amaurosis an inherited retinopathy and mutations in that gene can abolish interaction with this protein which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies and in glial cytoplasmic inclusions in multiple system atrophy with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq Aug 2011]

Gene Symbol:   NUB1
Gene Name:   negative regulator of ubiquitin-like proteins 1
Aliases:   BS4, NUB1L, NYREN18
RefSeq:   NC_000007.13 NT_007914.15
Ensembl:   ENSG00000013374
Entrez:   51667
UniGene:   Hs.647082
Chromosome Mapping:   7q36

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