PrimePCR™ ddPCR™ Expression EvaGreen® Assay: MDM4, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCED0038792; exonic

List Price:    $138.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5006687
Chromosome Location:   1:204494629-204495489question
Amplicon Length:   67

Gene Information

This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity and have been shown to be overexpressed in a variety of human cancers. However unlike MDM2 which degrades p53 this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq Feb 2011]

Gene Symbol:   MDM4
Gene Name:   Mdm4 p53 binding protein homolog (mouse)
Aliases:   DKFZp781B1423, HDMX, MDMX, MGC132766, MRP1
RefSeq:   NC_000001.10 NT_004487.19
Ensembl:   ENSG00000198625
Entrez:   4194
UniGene:   Hs.497492
Chromosome Mapping:   1q32

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