PrimePCR™ ddPCR™ Expression EvaGreen® Assay: CASP1, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCED0038605; exonic

List Price:    $134.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5006605
Chromosome Location:   11:104896927-104897043question
Amplicon Length:   87

Gene Information

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits large and small that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1 a cytokine involved in the processes such as inflammation septic shock and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq Mar 2012]

Gene Symbol:   CASP1
Gene Name:   caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
Aliases:   ICE, IL1BC, P45
RefSeq:   NC_000011.9 NT_033899.8
Ensembl:   ENSG00000137752
Entrez:   834
UniGene:   Hs.2490
Chromosome Mapping:   11q23

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