PrimePCR™ ddPCR™ Expression EvaGreen® Assay: MC1R, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCED0037866; exonic

List Price:    $134.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5006295
Chromosome Location:   16:89984743-89984922question
Amplicon Length:   150

Gene Information

This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein a seven pass transmembrane G protein coupled receptor controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq Jul 2008]

Gene Symbol:   MC1R
Gene Name:   melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Aliases:   CMM5, MGC14337, MSH-R, SHEP2
RefSeq:   NC_000016.9 NG_012026.1 NG_027810.1 NT_010542.15
Ensembl:   ENSG00000258839
Entrez:   4157
UniGene:   Hs.513829
Chromosome Mapping:   16q24.3

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