PrimePCR™ ddPCR™ Expression EvaGreen® Assay: SIGLEC12, Human

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PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCED0037035; exonic

List Price:    $130.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5006067
Chromosome Location:   19:52003308-52003443question
Amplicon Length:   106

Gene Information

Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein upon tyrosine phosphorylation has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq Jul 2008]

Gene Symbol:   SIGLEC12
Gene Name:   sialic acid binding Ig-like lectin 12
Aliases:   FLJ38600, S2V, SIGLECL1, SLG, Siglec-XII
RefSeq:   NC_000019.9 NT_011109.16
Ensembl:   ENSG00000254521
Entrez:   89858
UniGene:   Hs.249741
Chromosome Mapping:   19q13.4

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