PrimePCR™ ddPCR™ Expression EvaGreen® Assay: NOG, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCED0019292; Exonic

List Price:    $134.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5004275
Chromosome Location:   17:54672465-54672571question
Amplicon Length:   77

Gene Information

The secreted polypeptide encoded by this gene binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes such as neural tube fusion and joint formation. Recently several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus rat and mouse. [provided by RefSeq Jul 2008]

Gene Symbol:   NOG
Gene Name:   noggin
Aliases:   SYM1, SYNS1
RefSeq:   NC_000017.10 NG_011958.1 NT_010783.15
Ensembl:   ENSG00000183691
Entrez:   9241
UniGene:   Hs.248201
Chromosome Mapping:   17q22

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